As connective tissue is found throughout the body, Marfan syndrome can affect the skeleton, eyes, heart, blood vessels, nervous system, skin, and lungs. In critical cases, it can prove to be fatal at any age. The disorder was named after Antoine Marfan, who was a French pediatrician. Antoine first described the syndrome in 1896, and the gene linked to the disease was first identified by Francesco Ramirez in 1991.